We know that women who become depressed during pregnancy may not take appropriate care of themselves or even make it to prenatal appointments, and there is evidence that maternal depression itself has an adverse effect on fetal and neonatal well being. While this report does not offer explicit guidelines for individual patients, the study unequivocally suggests that women taking antidepressants who anticipate pregnancy need to address with their doctors not only potential risks to their babies if they continue taking the drugs but also the risk that their disease may recur if they stop antidepressants. Only by considering both sides of this risk/benefit equation can patients make informed decisions.